* Early good results for Pfizer , BioNTech vaccine prospect* U.S. marks record one-working day spike in virus circumstances* FedEx (NYSE:) jumps on quarterly profit, revenue conquer* Indexes: Dow off .08%, S&P up .27%, Nasdaq up .56% (Adds remarks, updates costs)By Pawel Goraj and Devik JainJuly 1 (Reuters) – The S&P 500 and Nasdaq rose on Wednesday as growing hopes of a COVID-19 vaccine offset fears of another round of lockdowns subsequent a record surge in coronavirus situations in the United States.A COVID-19 vaccine made by Pfizer Inc (NYSE:) PFE.N and German biotech business BioNTech showed assure and was uncovered to be perfectly tolerated in early-stage human trial, the businesses reported. shares rose 4.8% on the news, one of the greatest enhance to the S&P 500 index, while BioNTech attained 3%, assisting improve the mood on Wall Road after the United States registered 47,000 new coronavirus instances on Tuesday, the major 1-day spike given that the start of the pandemic. on the progress in different COVID-19 vaccine systems are being closely viewed by buyers, and have been partly accountable for Wall Street’s modern rally. The S&P 500 shut its most effective quarter because 1998 on Tuesday.The market in standard has reacted positively to these bits of information as they are all tied to the COVID problem, said Andre Bakhos, managing director at New Vines Capital LLC in Bernardsville, New Jersey. “The COVID-19 is the linchpin to the market proper now.”The S&P 500 on Tuesday secured its most important quarterly percentage achieve in far more than two a long time fueled by unparalleled degrees of fiscal and financial stimulus.Buyers have also focused on signals of an economic recovery with the easing of coronavirus-induced lockdowns. Data on Wednesday showed a slump in world producing was easing in June, with U.S. figures hitting their optimum level in more than a 12 months. Institute for Supply Administration (ISM) reported its index of countrywide manufacturing facility exercise jumped to a reading through of 52.6 last thirty day period from 43.1 in Might, ending 3 straight months of contraction, or readings down below 50.On Thursday, all eyes will be on the Labor Department’s nonfarm payrolls report.”The production amount adds a boost to trader assurance. And now the market is positioning by itself in anticipation for tomorrow’s numbers,” Bakhos included.The ADP (NASDAQ:) Countrywide Employment Report on Wednesday confirmed U.S. personal payrolls increased by 2.369 million jobs, but continue to less than expected in June. 11:43 a.m. ET the Dow Jones Industrial Ordinary was down 19.88 details, or .08%, at 25,793.00, the S&P 500 was up 8.47 factors, or .27%, at 3,108.76 and the Nasdaq Composite was up 56.63 details, or .56%, at 10,115.39.Battered cruise line operators Norwegian Cruise Line Holdings Inc NCLH.N , Royal Caribbean Cruises Ltd RCL.N and Carnival Corp (LON:) CCL.N rose involving 3.6% and 6.%.Drugmaker Amgen Inc rose 5% immediately after a federal appeals courtroom upheld two patents for the drugmaker’s multibillion-dollar rheumatoid arthritis drug Enbrel. Corp FDX.N jumped 14.3% soon after posting greater-than-anticipated quarterly profit and revenue, served by a surge in pandemic-fueled household deliveries. issues virtually matched advancers on the NYSE and outnumbered them 1.46-to-1 on the Nasdaq.The S&P index recorded 13 new 52-7 days highs and no new low, though the Nasdaq recorded 64 new highs and 8 new lows.